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caliercortin 50ml

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caliercortin 50ml (Calier Lab) it´s an Anti-inflammatory, anti-exudative, anti-proliferative and anti-allergic, based on Dexamethasone for horses, cattle, pigs, sheep, goats, cats and dogs.

Description

caliercortin 50ml (Calier Lab) it´s an Anti-inflammatory, anti-exudative, anti-proliferative and anti-allergic, based on Dexamethasone for horses, cattle, pigs, sheep, goats, cats and dogs.

Composition:
Dexamethasone (21 sodium phosphate) 0.4 g.
Aqueous Excipient c.s.p. 100 ml

Action:
Anti-inflammatory, anti-exudative, anti-proliferative and anti-allergic. Dexamethasone is a corticosteroid with a mechanism of action and intensity of effect 4 to 5 times higher than the same concentration of a crystalline prednisolone suspension.
With CALIERCORTIN you get a hormonal effect and a thermacodinic effect The hormonal action consists in the regulation of the metabolism of carbohydrates: it increases glycemia, stimulates the neoformation of sugars from proteins and fats, increases hepatic glucose. It has antitoxic and antiallergic action.
The pharmacodynamic action consists of an intense inhibition of the mesenchymal, anti-inflammatory, anti-exudative and antiproliterative reaction.

Indications:
In all target species, against inflammations caused by infections, allergies, trauma or other etiologies. Shock and circulatory collapse, bovine ketosis.

Contraindications:
Don´t administer to animals with bacterial diseases without concomitant antibiotic therapy, fungal or viral infections, renal and / or hepatic insufficiency, congestive heart failure, osteoporosis, bone fractures, diabetes mellitus, degenerative ocular diseases or corneal ulcers, hyperadrenocorticalism, animals undergoing immunological treatment.
Do not administer in pregnant females during the last third of pregnancy, as it can lead to premature delivery followed by dystocia, fetal death, placental retention and metritis. Dairy production of lactating animals may temporarily decrease with the administration of Dexamethasone.
Do not administer together with:
-Antidiabetics: the hyperglycemic action of corticosteroids can counteract the anti-diabetes effect.
-Barbiturates: parenterally, they can lead to a loss of the therapeutic efficacy of corticosteroids.
-Diuretic potassium deplectors: they can lead to significant hypokalemia with the consequent risk of cardiac, muscular pathological manifestations.
-Indomethacin: administered parenterally, it can lead to an increase in the incidence of gastrointestinal disorders and especially peptic ulcer.
-Salicylates: may lead to a plasma decrease in salicylates. In addition, the harmful effects on the gastric mucosa can be enhanced.
-Antihistamines: increase the degradation of Dexamethasone. Do not administer concomitant therapy with other corticosteroids.

In case of infectious or parasitic diseases, apply together with specific antibiotics or antiparasitic.
Prolonged use of the recommended doses for weeks or months may cause symptoms of Cushing, and abrupt discontinuation of treatment results in atrophy of the adrenal glands (hypoadrenocorticism).
Important: It is up to the veterinarian to establish emergency therapy in the cases cited contraindicated for use.

Restrictions of use:
Do not administer to horses whose meat is intended for human consumption.
For meat the waiting time is 5 days, for milk it is 3 days.

Collateral damage:
In cases of infections, the symptoms of it can be masked, such as pyrexia, laxity and lack of appetite.
It decreases organic defenses by predisposing the animal more easily to microbial infections. It causes delayed wound healing.
It can produce weakness of striated musculature.
In dogs and cats it can cause an increase in the enzymes Serum Alkaline Phosphatase (SAP) and Serum Pyruvic Glutamic Transaminase (SGPT), weight loss, anorexia, diarrhea (sometimes bloody), vomiting, polydipsia and polyuria. Euphoria and some changes in animal behavior have also been observed with improved attitude.
In horses, a dose greater than 5 mg / animal can cause lethargy, which usually remits within 24 hours. In some cases, it can cause laminitis.

Dosage:
Administration intramuscularly, subcutaneously or intravenously.
Cattle, sheep, goats, pigs and horses: 0.005-0.02 ml per kg of single dose live weight.
Canine: 0.0125-0.05 ml per kg of live weight single dose.
Feline: 0.025-0.075 ml per kg of live weight single dose.
Intra-articular administration:
Large animals: 0.5-2.5 ml.
Small animals: 0.125-1.25 ml, repeat if necessary, every 24-48 hours, for a maximum period of 5 days.

Dose for Horse & Camel in Race: 
Intramuscular and intravenous (IV or IM)
for race, average recommended dose:
– Camel: 5 doses, each dose every 1 day, 5 ml / day
– Horse: 5 doses, each dose every 1 day, 7 ml / day
last dose 5 days before the race

 

caliercortin-50ml
Injectable Solution
Steroid anti- inflammatory in injectable solution CALIER
Laboratory
Pharmaceutical
form
Injectable solution (Sol.i.)
Composition per ml:
Dexamethasone (sodium phosphate) 4 mg.
Pharmacological properties
Synthetic glucocorticoid derived from cortisol with an anti-inflammatory activity 25 times greater than
this, and with little mineralocorticoid activity.
Interactions and incompatibilities
Do not administer together with antidiabetics, barbiturates, potassium depleting diuretics,
indomethacin, salicylates, antihistamines.
Indications and species of destination
Horses, Dogs and Cats: Treatment of inflammatory and allergic processes; trauma; shock
and circulatory collapse. caliercortin-50ml caliercortin-50ml
Contraindications
• Except in emergency situations, do not use in animals suffering from diabetes mellitus,
chronic nephritis , kidney failure, heart failure or osteoporosis.
• Do not use in virosis during the viremic phase or in cases of systemic fungal infections.
• Do not use in animals with bacterial diseases without establishing the
appropriate antibiotic treatment .
• Do not use in animals with gastrointestinal or corneal ulcers, nor in individuals with
demodicosis.
• Do not administer intra-articularly if there are fractures, bacterial infections in the
joints or bone necrosis.
• Do not use in case of known hypersensitivity to the active substance, corticosteroids or to
any of the excipients.
Side effects
• Corticosteroids can cause iatrogenic hyperadrenocorticism
(Cushing’s syndrome) during treatment ; which could lead to a redistribution of body fat,
weight gain, weakness and loss of muscle mass and osteoporosis.
• During treatment, the hypothalamic adrenal pituitary axis is suppressed.
• After discontinuation of treatment, adrenal insufficiency may occur, which may lead to
adrenal cortical atrophy, with the possibility that the animal cannot cope properly.
to stressful situations. Therefore, efforts should be made to minimize
adrenal insufficiency problems after withdrawal of treatment.
• Systemically administered corticosteroids can cause polyuria, polydipsia, and
polyphagia, especially during the initial stages of treatment.
• Some corticosteroids can cause water and sodium retention and hypokalemia in
prolonged use.
• Systemic corticosteroids have caused calcium sedimentation on the skin (
cutaneous calcinosis ).
• Gastrointestinal ulcers have been reported in animals treated with corticosteroids, which can
worsen if nonsteroidal anti-inflammatory drugs have also been administered, as well as in
animals with spinal trauma.
• The administration of corticosteroids can cause an increase in the size of the liver
(hepatomegaly) with an increase in liver enzymes. Changes in
biochemical and hematological parameters may occur . Transient hyperglycemia may also occur.
Administration route
Intramuscular, subcutaneous, intravenous or intraarticular. Equine
Dosage caliercortin-50ml caliercortin-50ml caliercortin-50ml
: 0.05 to 0.20 ml / 10 kg bw in a single dose.
Dogs: 0.125 to 0.50 ml / 10 kg bw in a single dose.
Cats: 0.25 to 0.75 ml / 10 kg bw in a single dose.
Intraarticular administration:
Equidae: 0.5 2.5 ml at the application site.
Small Animals: 0.125 1.25 ml at the application site.
• If necessary, the dose can be repeated every 24 to 48 hours, for a maximum of 5 days.
Waiting time
Meat:
Equine: 28 days.
• Its use is not authorized in mares whose milk is used for human consumption. Conservation
method
Store at a temperature below 30 ° C. Keep the vial in the outer carton in
order to protect it from light.
Observations
With a veterinary prescription.
Presentation
Vials with 10 and 50 ml.https://enongvetmedication.com/

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