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dexatat

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dexatat Dexamethasone is one of the synthetic glucocorticoids. Compared to the cortisol synthesized i n the body, dexamethasone has a 25 times dexatat

Description

dexatat Dexamethasone is one of the synthetic glucocorticoids. Compared to the cortisol synthesized i n the body, dexamethasone has a 25 times stronger anti-inflammatory effect. Because of its negligible mineralocorticoid activity, dexamethasone is classified as a glucocorticoid. Dexamethasone interferes with the hypothalamic-pituitary control loop via an inhibition of ACTH synthesis (in the sense of negative feedback), which leads to an inhibition of endogenous cortisol secretion in the adrenal cortex (NNR) and can lead to NNR insufficiency with prolonged use. Dexamethasone develops its pharmacological properties after passive absorption into the cells: specific genes are regulated after binding to the cytosolic receptor.
The sodium salt of dexamethasone phosphate is characterized by its high water solubility. The stable, water-clear injection solution Dexatat ® therefore offers the advantage that intravenous administration can also take place. This is of particular importance in all acute cases where an immediate effect is desired. Furthermore, the intra-articular injection of the solution is particularly well tolerated.

indications

Symptomatic therapy for:

Allergies and allergic skin diseases
inflammatory, non-infectious diseases of the musculoskeletal system
MMA complex of the mother sow
Primary acetonemia in the cow
Brain and spinal cord swelling or edema after trauma / discopathy / tumors in dogs
Triggering birth in ruminants
Certain forms of shock (endotoxin shock, anaphylactic shock) in dogs and cats

For intravenous, intramuscular, subcutaneous and intra-articular injection:

Horse, cattle, pig, sheep, goat:

0.020 – 0.060 mg dexamethasone / kg body weight corresponding to approx. 1 – 3 ml Dexatat ® / 100 kg body weight

Dog Cat:

0.100 – 0.250 mg dexamethasone / kg body weight corresponding to approx. 0.25 – 0.63 ml Dexatat ® / 5 kg body weight

intra-articular injection:

Large animal: 2 -10 mg locally (corresponding to approx. 1 – 5 ml)
Small animal: 0.25 – 5 mg locally (corresponding to approx.0.13 – 2.5 ml)

Depending on the severity of the disease, application once or possibly several times.

limitations

Contraindications

last third of pregnancy in ruminants
Diabetes mellitus
Gastrointestinal ulcers
osteoporosis
active immunization
acute bacterial and viral infections (except in life-threatening situations)
systemic
septic processes

 

Precautions

long-term therapy (more than 14 days) must not be stopped abruptly.

unwanted effects

VetVigilance: Report pharmacovigilance

The frequency and extent of occurrence depend on individual factors of the patient, on the dosage and the duration of therapy.
The following effects can occur especially when the therapy is long:

increased risk of infection
delayed wound healing
Gastrointestinal ulcers
Osteoporosis, arthropathy, skin atrophy, muscle wasting
Birth in ruminants in the last third of pregnancy
decreased milk yield
decreased glucose tolerance
Lowering the seizure threshold
ACTH suppression, NNR inactivity atrophy

Edible tissues: cattle, sheep, goat, horse 16 days; Pig 4 days
milk: 4 days

interactions

Potassium loss from certain diuretics (loop diuretics and thiazides) is increased. This results in reduced cardiac glycoside tolerance
Combination with non-steroidal anti-inflammatory drugs (NSAID) increases the risk of gastrointestinal ulcerations
The insulin requirement of diabetics can be increased
Pharmaceuticals that induce the liver enzymes reduce the effect

Other notices

Do not use Dexatat ® after the expiry date!
Keep Dexatat ® out of the reach of children!
Storage information: Protect from light and keep at room temperature (15 – 25 ° C). Use-up period after first withdrawal: 28 days.

packs

Bottle with 50 ml and 100 ml

Submission category : B

Swissmedic No. 36,999

Information status : 02/2007  https://enongvetmedication.com/

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