COMPOSITION : Excenel Flow injection suspension is a light-white, sterile, flowable suspension containing 50 mg of ceftiofur hydrochloride equivalent to 50 mg of ceftiofur in each ml.
Ceftiofur is a broad spectrum bactericidal cephalosporin antibiotic resistant to B-Iactamase enzymes. The other cephalosporin group acts like antibiotics by preventing cell wall synthesis.
The effect of ceftiofur on bacteria is as follows; High susceptibility bacteria (MIC <2 ugg / ml): Streptococci (except enterococci), many gram-positive bacteria susceptible to benzyl penicillin, E. coli, Klebsiella sp., Proteus sp. and Salmonella sp., actinobacillus sp., Haemophilus sp., Pasteurella sp., Clostridium sp. and Fusobacterium sp. Bacteria with moderate sensitivity (MIC 4 /g / ml): Staphylococcus aureus, some Citrobacter sp., Enterobacter sp., Some Pseudomonas aeruginosa strains and Serratia sp. Resistant bacteria (MIC> 8 /g / ml): Acinetobacter sp., Bordetella sp., Some Enterobacter sp. and Serratia sp. some Pseudomonas aeruginosa strains, enterococci and methicillin resistant Staphylococcus aureus strains.
After ceftiofur administration, the main metabolite is desfuroylceftiofur. The maximum concentration and reach time ranged from 11 ± 1.69 /g / ml and 1-4 hours after intramuscular administration and 8.56 ± 1.89 /g / ml and 1-5 hours after subcutaneous administration. The half-life was 12 ± 2.63 hours after intramuscular administration and 11.5 ± 2.57 hours after subcutaneous administration. Plasma concentration was 1.47 ± 0.38 /g / ml following intramuscular administration and 0.926 ± 0.257 /g / ml following subcutaneous administration at 24 hours. Plasma concentration was 0.34 ± 0.11 /g / ml following intramuscular administration at the end of the hour and 0.271 ± 0.086 lm following subcutaneous administration.
The concentrations reached at the end of the forty-eighth hour were Mannheimia sp. (Pasteurella haemolytica), Pasteurella multocida, Haemophilus somnus and Fusobacterium necrophorum. Ceftiofur is highly dispersed in tissues after application. However, the passage through the membranes is not high. 60-80% of the body is excreted in the urine and the rest is excreted in the feces. Calcium (66.00 mg), sodium (10.32 mg), magnesium (222.00 mg), phosphorus (0)
Excenel Flow USAGE AREA and INDICATIONS
Excenel Flow injection suspension is used for the treatment of respiratory and soft tissue infections caused by ceftiofur sensitive bacteria in cattle. Excenel® Flow injection suspension is indicated for the treatment of the following bacterial infections in cattle.
- Mannheimia sp. (Pasteurella haemolytica), Pasteurella multocida and Haemophilus somnus
- Acute interdigital necrobacillosis (foot rot, pododermatitis) caused by Fusobacterium necrophorum and Bacteroides melaninogenicus
- Acute postpartum (puerperal) metritis caused by E.coli, Arcanobacterium pyogenes and Fusobacterium necrophorum within 14 days after birth
DOSAGE AND ADMINISTRATION
Excenel Flow injection suspension can be administered intramuscularly and subcutaneously. The recommended dosage of Excenel Flow injection suspension in cattle is 1 mg / kg body weight / day. (1 ml / 50 kg body weight). Duration of treatment is 3 days. If there is no result from the three-day treatment, the application can be continued for 2 days. In the case of large volumes, the total volume should be divided into 15 ml volumes and applied to different regions. Shake well before use.
After intramuscular and subcutaneous administration, discoloration at the injection site may persist for more than 11 days in the neck and 28 days in the hind leg. Since these regions will not be evaluated during slaughter, they may cause losses in the amount of edible meat. Betalactams have side effects that can cause death in susceptible animals starting with mild allergy.
DRUG RESIDENCES IN FOOD
Drug Residue Removal Time (ikas) ; Cattle should not be referred to slaughter during the treatment and 6 days after the last drug administration. The residual purification time for cow’s milk is “0” days.
It should not be used in animals previously known to be susceptible to ceftiofur or other B-Iactam antibiotics. Do not inject intravenously.
Use in Pregnancy
Studies in experimental animals revealed that 1000 mg / kg body weight / day dose had no effect on reproductive performance and did not show teratogenic effect. The safety of ceftiofur in pregnant cows has not been specifically studied.