PRIALT

Description

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Details on the medication ziconotide (Prialt)
To treat severe chronic pain, one can utilise the drug ziconotide (Prialt). It is applied to individuals who are either intolerant of other treatments or resistant to them, including intrathecal morphine, adjuvant therapies, and analgesics.

Titration of the dose:

To reach a maximum dose of 19.2 mcg/day (0.8 mcg/hour) by day 21, the manufacturer advises titrating the dose by 2.4 mcg/day (0.1 mcg/hour) or less every second or third day.
At day 21, the typical dose is 6.9 mcg/day (0.29 mcg/hour).
On the basis of analgesia and tolerability, experts advise that the upward titration dose should not, however, exceed 0.5 mcg/day per week.
The advantages and disadvantages should be evaluated if analgesia is urgently required.